MersV1, Main, Exploration, bibRecord, 001F22

Receptor-binding domain as a target for developing SARS vaccines.

Identifieur interne : 001F22 ( Main/Exploration ); précédent : 001F21; suivant : 001F23

Receptor-binding domain as a target for developing SARS vaccines.

Auteurs : Xiaojie Zhu [République populaire de Chine] ; Qi Liu ; Lanying Du ; Lu Lu ; Shibo Jiang

Source :

Journal of thoracic disease [ 2072-1439 ] ; 2013.

RBID : pubmed:23977435

Abstract

A decade ago, severe acute respiratory syndrome (SARS) coronavirus (SARS-CoV) caused a global pandemic with a mortality rate of 10%. Reports of recent outbreaks of a SARS-like disease caused by Middle East respiratory syndrome coronavirus (MERS-CoV) have raised serious concerns of a possible reemergence of SARS-CoV, either by laboratory escape or the presence of a natural reservoir. Therefore, the development of effective and safe SARS vaccines is still needed. Based on our previous studies, we believe that the receptor-binding domain (RBD) in the S1 subunit of the SARS-CoV spike (S) protein is the most important target for developing a SARS vaccine. In particular, RBD of S protein contains the critical neutralizing domain (CND), which is able to induce highly potent neutralizing antibody response and cross-protection against divergent SARS-CoV strains. Furthermore, a RBD-based subunit vaccine is expected to be safer than other vaccines that may induce Th2-type immunopathology. This review will discuss key advances in the development of RBD-based SARS vaccines and the possibility of using a similar strategy to develop vaccines against MERS-CoV.

DOI: 10.3978/j.issn.2072-1439.2013.06.06
PubMed: 23977435

Affiliations:

République populaire de Chine

Le document en format XML

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<front><div type="abstract" xml:lang="en">A decade ago, severe acute respiratory syndrome (SARS) coronavirus (SARS-CoV) caused a global pandemic with a mortality rate of 10%. Reports of recent outbreaks of a SARS-like disease caused by Middle East respiratory syndrome coronavirus (MERS-CoV) have raised serious concerns of a possible reemergence of SARS-CoV, either by laboratory escape or the presence of a natural reservoir. Therefore, the development of effective and safe SARS vaccines is still needed. Based on our previous studies, we believe that the receptor-binding domain (RBD) in the S1 subunit of the SARS-CoV spike (S) protein is the most important target for developing a SARS vaccine. In particular, RBD of S protein contains the critical neutralizing domain (CND), which is able to induce highly potent neutralizing antibody response and cross-protection against divergent SARS-CoV strains. Furthermore, a RBD-based subunit vaccine is expected to be safer than other vaccines that may induce Th2-type immunopathology. This review will discuss key advances in the development of RBD-based SARS vaccines and the possibility of using a similar strategy to develop vaccines against MERS-CoV. </div>
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Receptor-binding domain as a target for developing SARS vaccines.

Receptor-binding domain as a target for developing SARS vaccines.

Source :

Abstract

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Le document en format XML

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